Permanent diaphragmatic deficits and spontaneous respiratory plasticity in a mouse model of incomplete cervical spinal cord injury
نویسندگان
چکیده
High spinal cord injuries (SCI) lead to permanent respiratory insufficiency, and the search for new therapeutics restore this function is essential. To date, most documented preclinical model high SCI rat cervical C2 hemisection. However, molecular studies with are limited due poor availability of genetically modified specimens. The aim work was evaluate pathophysiology activity following a injury at different times post-injury in C57BL/6 mouse model. No significant spontaneous recovery diaphragmatic observed up 30 days eupneic condition. during challenge, i.e. mild asphyxia, partial restoration injured diaphragm 7 post-injury, corresponding crossed phrenic phenomenon. Interestingly, recording between 2 bursts on side showed an amplitude increase 1–7 reflecting change motoneuronal excitability. This inter-burst excitability returned pre-injured values when phenomenon started be effective post-injury. Taken together, these results demonstrate ability system express long-lasting plasticity hemisection animals can used study pathophysiological effects phenomena.
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ژورنال
عنوان ژورنال: Respiratory Physiology & Neurobiology
سال: 2021
ISSN: ['1569-9048', '1878-1519']
DOI: https://doi.org/10.1016/j.resp.2020.103568